The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides.
نویسندگان
چکیده
Two alternative approaches to the synthesis of novel 6-(fluoromethyl)purine bases and nucleosides are described either by direct deoxyfluorination or by multistep functional group transformations starting from 6-(hydroxymethyl)purines. 6-(fluoromethyl)purine ribonucleoside displayed significant cytostatic effects.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 3 16 شماره
صفحات -
تاریخ انتشار 2005